The seven-time All England club champion will also aim for a record 24th Grand Slam title. Against the great American who has the potential to become the first unseeded woman to win Wimbledon.
With just three months to go before her 41st birthday, Williams has not played on the tour since tearing up against Ariaksandra Sasnovich in the first round of the 2021 Wimbledon Singles draw.
Sasnovich told AFP at the French Open last month, "I hope I'm not the last player to beat her at Wimbledon,"
"She is a great champion and I want to see her again."
Maybe Sasnovich will not participate in the Wimbledon at All England Club due to the ban on Russian and Belarusian players, but she has fulfilled Williams' wish to return.
The American star has been disappointingly left out of 23 major tournaments since winning her seventh Australian Open title while pregnant in 2017.
In 2018 and 2019, she was runner-up at Wimbledon and the US Open, as Margaret Court's all-time record of 24 Grand Slams remains out of reach.
"Did I ever doubt I'd be back? Of course, if not I would not be honest," Williams said after returning to the doubles court in Eastbourne on Tuesday.
"It feels good, but I always try to stay fit because I don't know when I'm going to play Wimbledon."
Williams remains the last woman to successfully defend a Wimbledon title in 2016.
In 2016, Williams remains the last woman to fruitfully defend her Wimbledon title